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open-medica/open-medical-skills

drugbank-search

Access 17,430+ drugs (13,166 small molecules + 4,264 biotech drugs) with high-performance SQLite backend. Search by name, therapeutic category, elimination half-life, or molecular similarity.

First seen Apr 30, 2026

Installation

$ npx skills add open-medica/open-medical-skills --skill drugbank-search
View on skills.sh ↗ GitHub repository ↗

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More details

Agent compatibility

Declared targets from SKILL.md / docs. Unmarked agents are not listed — the skill may still install via the CLI.

Claude Code Not declared
Cursor Not declared
Codex Not declared
GitHub Copilot Not declared
Windsurf Not declared
Gemini CLI Not declared
Cline Not declared
OpenCode Not declared

Repository health

Stars 15
License LICENSE
Default branch main
Open issues 0
Status Active

Package contents

Files included with this skill beyond the listing page.

  • skill md SKILL.md 4,813 B
  • docs SUMMARY.md 214 B

History

  1. First seen on skills.sh
  2. First recorded snapshot · 20 installs

SKILL.md

DrugBank Comprehensive Drug Database

Access detailed pharmacological data for over 17,430 drug entries -- including 13,166 small-molecule drugs and 4,264 biotech/biologic products -- through a high-performance SQLite-backed local database. This skill enables AI agents to search by drug name, therapeutic category, mechanism of action, elimination half-life, molecular weight, or structural similarity, providing clinicians and pharmacists with rapid access to comprehensive drug monograph data without relying on external API rate limits.

Quick Install

npx skills add Open-Medica/open-medical-skills --skill drugbank-search

What It Does

  • Drug monograph lookup with detailed pharmacological profiles including mechanism of action, pharmacokinetics (absorption, distribution, metabolism, excretion), therapeutic indications, and contraindications
  • Multi-field search by generic name, brand name, therapeutic category (ATC classification), molecular target, or DrugBank accession number with fuzzy matching support
  • Pharmacokinetic parameter queries to find drugs by elimination half-life, protein binding percentage, volume of distribution, or bioavailability ranges
  • Drug classification browsing through the Anatomical Therapeutic Chemical (ATC) hierarchy, enabling category-based exploration of drug classes
  • Local SQLite backend for high-performance offline queries with sub-millisecond response times, no external API dependency, and no rate limiting

Clinical Use Cases

  • Formulary comparison: A hospital pharmacist evaluating therapeutic alternatives for a drug shortage can search all drugs within the same ATC class, compare half-lives and dosing intervals, and identify suitable substitutions with matching pharmacokinetic profiles.
  • Pharmacology education: A medical student studying antihypertensives can browse the entire class hierarchy, compare mechanisms of action across ACE inhibitors vs ARBs vs calcium channel blockers, and review key PK parameters side-by-side.
  • Drug development research: A pharmaceutical researcher can query the database for all approved kinase inhibitors, examine their molecular targets, and identify gaps in the therapeutic landscape for novel drug candidates.
  • Clinical pharmacokinetics consultation: A clinical pharmacologist adjusting renal dosing can quickly look up the fraction of drug eliminated renally, protein binding, and active metabolite profiles to guide dosage modifications.

Safety & Evidence

  • Safety Classification: Safe -- This skill provides read-only access to curated drug reference data. It does not prescribe medications, calculate doses for individual patients, or interact with electronic health records. Drug information is sourced from peer-reviewed pharmacological databases.
  • Evidence Level: High -- DrugBank is a widely cited, peer-reviewed pharmaceutical knowledge base (cited in over 18,000 publications). Data undergoes expert curation by pharmacists and pharmaceutical scientists at the University of Alberta.

Example Usage

Look up pharmacokinetic parameters for a specific drug:

Search DrugBank for lisinopril. Show me its mechanism of action,
elimination half-life, protein binding, renal clearance percentage,
and all available brand names.

Find drugs within a therapeutic category by half-life:

Search for all beta-adrenergic blocking agents (ATC class C07)
with an elimination half-life greater than 12 hours. Sort by
half-life descending and include bioavailability data.

Technical Details

  • Category: Pharmacy
  • Author: OMS Contributors (original: openpharma-org)
  • License: MIT
  • Data Source: DrugBank Open Data (CC BY-NC 4.0 for academic use)
  • Backend: SQLite database with indexed columns for fast querying
  • Coverage: 17,430+ drug entries, 13,166 small molecules, 4,264 biotech drugs
  • Dependencies: SQLite3 client, Python (optional for advanced queries)

References

This skill is part of Open Medical Skills, a curated marketplace of medical AI skills maintained by physicians for physicians and the healthcare industry.